Rapid Communication Kruppel-Like Factor 2 Inhibits Protease Activated Receptor-1 Expression and Thrombin-Mediated Endothelial Activation
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Thrombin-Mediated Endothelial Activation Kruppel-Like Factor 2 Inhibits Protease Activated Receptor-1 Expression and Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2006 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000215638.53414.99 2006;26:1185; originally published online March 2, 2006; Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/26/5/1185 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Kruppel-like factor 2 inhibits protease activated receptor-1 expression and thrombin-mediated endothelial activation.
OBJECTIVE The serine protease thrombin can dramatically alter endothelial gene expression in a manner that confers a proinflammatory phenotype. Recent studies have identified the Kruppel-like factor 2 (KLF2) as a critical regulator of endothelial gene expression. Herein, we provide evidence that KLF2 inhibits thrombin-mediated endothelial activation via alterations in expression of its principa...
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Endothelial cells normally form a dynamically regulated barrier at the blood-tissue interface, and breakdown of this barrier is a key pathogenic factor in inflammatory disorders such as sepsis. Pro-inflammatory signaling by the blood coagulation protease thrombin through protease activated receptor-1 (PAR1) can disrupt endothelial barrier integrity, whereas the bioactive lipid sphingosine 1-pho...
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تاریخ انتشار 2006